Hemp Studies

               

STUDIES:

Cannabidiol, a Cannabis sativa constituent, as an anxiolytic drug.

Topical and Systemic Cannabidiol Improves Trinitrobenzene Sulfonic Acid Colitis in Mice.

Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer.

The therapeutic potential of the endocannabinoid system for Alzheimer's disease.

Non-THC cannabinoids counteract prostate carcinoma growth in vitro and in vivo: pro-apoptotic effects and underlying mechanisms.

Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors.

Cannabidiol exerts anti-convulsant effects in animal models of temporal lobe and partial seizures.

Cannabinoid-like anti-inflammatory compounds from flax fiber.

Cannabidiol in Inflammatory Bowel Diseases: A Brief Overview.

The potential for clinical use of cannabinoids in treatment of cardiovascular diseases.

Cannabidiol reduces lipopolysaccharide-induced vascular changes and inflammation in the mouse brain: an intravital microscopy study.

Cannabidiol Reduces Aβ-Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPARγ Involvement.

Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimers' disease.

Evaluation of the Cyclooxygenase Inhibiting Effects of Six Major Cannabinoids Isolated from Cannabis sativa.

Role of Myeloid-Derived Suppressor Cells in Amelioration of Experimental Autoimmune Hepatitis Following Activation of TRPV1 Receptors by Cannabidiol.

Cannabidiol causes activated hepatic stellate cell death through a mechanism of endoplasmic reticulum stress-induced apoptosis.

Cannabidiol, a Major Phytocannabinoid, as a Potent Atypical Inhibitor for Cytochrome P450 2D6.

Brief Report: Cannabidiol Prevents the Development of Cold and Mechanical Allodynia in Paclitaxel-Treated Female C57Bl6 Mice.

Cannabidiol Reduces Intestinal Inflammation through the Control of Neuroimmune Axis.

Phytocannabinoids for use in the treatment of cancer - Patent GB2478595 (A) ― 2011-09-14.

US Patent Application 20110257256 - CANNABINOIDS FOR USE IN TREATING OR PREVENTING COGNITIVE IMPAIRMENT AND DEMENTIA.

Influence of agroclimatic conditions on content of main cannabinoids in Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes.

Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes.

Safety and Side Effects of Cannabidiol, a Cannabis sativa Constituent.

Cannabidiol as an anti-arrhythmic, the role of the CB1 receptors.

Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy.

The Non-Psychoactive Plant Cannabinoid, Cannabidiol Affects Cholesterol Metabolism-Related Genes in Microglial Cells.

Cannabidiol decreases body weight gain in rats: Involvement of CB2 receptors.

Cannabidiol improves brain and liver function in a fulminant hepatic failure-induced model of hepatic encephalopathy in mice.

Effects of intracisternal administration of cannabidiol on the cardiovascular and behavioral responses to acute restraint stress.

Modulation of Auditory and Visual Processing by Delta-9-Tetrahydrocannabinol and Cannabidiol: an fMRI Study.

CANNABIDIOL INHIBITS PATHOGENIC T-CELLS, DECREASES SPINAL MICROGLIAL ACTIVATION AND AMELIORATES MULTIPLE SCLEROSIS-LIKE DISEASE IN C57BL/6 MICE.

Anti-Aversive Effects of Cannabidiol on Innate Fear-Induced Behaviors Evoked by an Ethological Model of Panic Attacks Based on a Prey vs the Wild Snake Epicrates cenchria crassus Confrontation Paradigm.

Memory-rescuing effects of cannabidiol in an animal model of cognitive impairment relevant to neurodegenerative disorders.

Interaction between non-psychotropic cannabinoids in marihuana: effect of cannabigerol (CBG) on the anti-nausea or anti-emetic effects of cannabidiol (CBD) in rats and shrews.

Inhibitory Effect of Standardized Cannabis sativa Extract and Its Ingredient Cannabidiol on Rat and Human Bladder Contractility.

Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients.

Effects on sleep and dopamine levels of microdialysis perfusion of cannabidiol into the lateral hypothalamus of rats.

Cannabidiol induces programmed cell death in breast cancer cells by coordinating the crosstalk between apoptosis and autophagy.

Regulation of nausea and vomiting by cannabinoids.

Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1.

Cannabis with high cannabidiol content is associated with fewer psychotic experiences.

Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report.

The endocannabinoid system in the regulation of emotions throughout lifespan: a discussion on therapeutic perspectives.

Cannabidiol protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress, inflammatory response, and cell death.

Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress.

Cannabidiol reduces brain damage and improves functional recovery after acute hypoxia-ischemia in newborn pigs.

Cannabidiol-treated Rats Exhibited Higher Motor Score After Cryogenic Spinal Cord Injury.

Prospects for cannabinoid therapies in basal ganglia disorder.

Phytocannabinoids as novel therapeutic agents in CNS disorders.

Plasma cannabinoid pharmacokinetics following controlled oral delta9-tetrahydrocannabinol and oromucosal cannabis extract administration.

Memory-rescuing effects of cannabidiol in an animal model of cognitive impairment relevant to neurodegenerative disorders.

Cannabidiol (CBD) as an Anti-Arrhythmic.

Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb.

Antidepressant-like effects of cannabidiol in mice: possible involvement of 5-HT receptors.

Effects of cannabidiol on amphetamine-induced oxidative stress generation in an animal model of mania.

Cannabinoid-mediated modulation of neuropathic pain and microglial accumulation in a model of murine type I diabetic peripheral neuropathic pain.

Cannabinoid receptor CB1 mediates baseline and activity-induced survival of new neurons in adult hippocampal neurogenesis.

Therapeutical use of the cannabinoids in psychiatry.

Cannabidiol protects retinal neurons by preserving glutamine synthetase activity in diabetes.

Ischemic Stroke.

Cannabidiol Displays Antiepileptiform and Antiseizure Properties In Vitro and In Vivo.

Acute administration of cannabidiol in vivo suppresses ischaemia-induced cardiac arrhythmias and reduces infarct size when given at reperfusion.

Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis.

Antitumorigenic Effects of Cannabinoids beyond Apoptosis.

Cannabidiol Attenuates Cardiac Dysfunction, Oxidative Stress, Fibrosis, and Inflammatory and Cell Death Signaling Pathways in Diabetic Cardiomyopathy.

Antidepressant-like effect of Delta(9)-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L.

Cannabidiol ameliorates cognitive and motor impairments in bile-duct ligated mice via 5-HT1A receptor activation.

Anti-tumoural effects of cannabinoid combinations - Patent TW201002315 (A) ― 2010-01-16.

Diabetic retinopathy: Role of inflammation and potential therapies for anti-inflammation.

A behavioural comparison of acute and chronic Delta9-tetrahydrocannabinol and cannabidiol in C57BL/6JArc mice.

Intra-dorsal periaqueductal gray administration of cannabidiol blocks panic-like response by activating 5-HT1A receptors.

Impact of cannabidiol on the acute memory and psychotomimetic effects of smoked cannabis: naturalistic study.

Decrease of plasminogen activator inhibitor-1 may contribute to the anti-invasive action of cannabidiol on human lung cancer cells.

Regulation of nausea and vomiting by cannabinoids.

Acute administration of cannabidiol in vivo suppresses ischaemia-induced cardiac arrhythmias and reduces infarct size when given at reperfusion.

Cannabidiol bioavailability after nasal and transdermal application: effect of permeation enhancers.

Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1.

Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb.

Effects of cannabidiol on amphetamine-induced oxidative stress generation in an animal model of mania.

Cannabidiol inhibitory effect on marble-burying behaviour: involvement of CB1 receptors.

Cannabidiol attenuates delayed-type hypersensitivity reactions via suppressing T-cell and macrophage reactivity.

Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain.

Treatment with cannabidiol reverses oxidative stress parameters, cognitive impairment and mortality in rats submitted to sepsis by cecal ligation and puncture.

Anticonvulsant effects of GWP42006 in vitro and in vivo in rat.

The neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic-ischemic brain damage in mice is mediated by CB(2) and adenosine receptors.

Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report.

Opposite Effects of Delta-9-Tetrahydrocannabinol and Cannabidiol on Human Brain Function and Psychopathology.

Time-dependent vascular actions of cannabidiol in the rat aorta.

Cannabidiol targets mitochondria to regulate intracellular Ca2+ levels.

Cannabidiol for the treatment of psychosis in Parkinson’s disease.

Modulation of effective connectivity during emotional processing by Delta9-tetrahydrocannabinol and cannabidiol.

Opposite Effects of Delta-9-Tetrahydrocannabinol and Cannabidiol on Human Brain Function and Psychopathology.

Cannabidiol: a promising drug for neurodegenerative disorders.

Cannabidiol, a safe and non-psychotropic ingredient of the marijuana plant Cannabis sativa, is protective in a murine model of colitis.

Cannabidiol ameliorates cognitive and motor impairments in mice with bile duct ligation.

Modulation of effective connectivity during emotional processing by Delta9-tetrahydrocannabinol and cannabidiol.

Therapeutic time window of cannabidiol treatment on delayed ischemic damage via high-mobility group box1-inhibiting mechanism.

Cannabinoids Δ9-Tetrahydrocannabinol and Cannabidiol Differentially Inhibit the Lipopolysaccharide-activated NF-κB and Interferon-β/STAT Proinflammatory Pathways in BV-2 Microglial Cells.

Non-psychotropic plant cannabinoids:new therapeutic opportunities from an ancient herb.

Cannabinoids, Endocannabinoids, and Related Analogs in Inflammation.

Evaluation of Prevalent Phytocannabinoids in the Acetic Acid Model of Visceral Nociception.

The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo.

Cannabinoids as novel anti-inflammatory drugs.

Cannabidiol Attenuates Cisplatin-Induced Nephrotoxicity by Decreasing Oxidative/Nitrosative Stress, Inflammation, and Cell Death.

The nonpsychotropic cannabinoid cannabidiol modulates and directly activates alpha-1 and alpha-1-Beta glycine receptor function.

Effects of cannabidiol on amphetamine-induced oxidative stress generation in an animal model of mania.

Cannabidiol Attenuates Myocardial Dysfunction, Fibrosis, Inflammation, Cell Death and Interrelated Signaling Pathways Associated With Diabetic Cardiomyopathy.

Cannabidiol decreases bone resorption by inhibiting RANK/RANKL expression and pro-inflammatory cytokines during experimental periodontitis in rats.

Cannabidiol-2',6'-Dimethyl Ether, a Cannabidiol Derivative, Is a Highly Potent and Selective 15-Lipoxygenase Inhibitor.

Cannabidiol reverses the reduction in social interaction produced by low dose Delta(9)-tetrahydrocannabinol in rats.

Mediation of Cannabidiol anti-inflammation in the Retina by Equilibrative Nucleoside Transporter and A2A Adenosine Receptor.

Antibacterial cannabinoids from Cannabis sativa: a structure-activity study.

Neuroprotective effects of cannabidiol in endotoxin-induced uveitis: critical role of p38 MAPK activation.

Effects of cannabidiol on schizophrenia-like symptoms in people who use cannabis.

The role of the endocannabinoid system in Alzheimer's disease: facts and hypotheses.

A comparative study on cannabidiol-induced apoptosis in murine thymocytes and EL-4 thymoma cell.

5-Lipoxygenase and anandamide hydrolase (FAAH) mediate the antitumor activity of cannabidiol, a non-psychoactive cannabinoid.

Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells.

The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Δ9-tetrahydrocannabinol, cannabidiol and Δ9-tetrahydrocannabivarin.

Cannabidiol, a nonpsychoactive Cannabis constituent, protects against myocardial ischemic reperfusion injury.

Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro.

Delayed treatment with cannabidiol has a cerebroprotective action via a cannabinoid receptor-independent myeloperoxidase-inhibiting mechanism.

Cannabidiol, unlike synthetic cannabinoids, triggers activation of RBL-2H3 mast cells.

The multidrug transporter ABCG2 (BCRP) is inhibited by plant-derived cannabinoids.

Interactions of cannabidiol with endocannabinoid signalling in hippocampal tissue.

Cannabidiol--recent advances.

Role of the Cannabinoid System in Pain Control and Therapeutic Implications for the Management of Acute and Chronic Pain Episodes.

Cannabidiol, a constituent of Cannabis sativa, modulates sleep in rats.

Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on β-amyloid-induced toxicity in PC12 cells.

Therapeutic potential of cannabinoids in CNS disease.

Gamma-irradiation enhances apoptosis induced by cannabidiol, a non-psychotropic cannabinoid, in cultured HL-60 myeloblastic leukemia cells.

Cannabidiol-transdermal delivery and anti-inflammatory effect in a murine model.

Cannabinoid effects on anxiety-related behaviours and hypothalamic neurotransmitters.

Cannabinoids might reduce spasticity in multiple sclerosis

Synthesis of a primary metabolite of cannabidiol.

Cannabinoids in clinical practice.

Cannabidiol and (−)Δ9-tetrahydrocannabinol are neuroprotective antioxidants.

Antianxiety effect of cannabidiol in the elevated plus-maze.

Allergenic properties of naturally occurring cannabinoids.

Effects of cannabidiol on behavioral seizures caused by convulsant drugs or current in mice.

The cannabinoids as potential antiepileptics.

Cannabidiol--antiepileptic drug comparisons and interactions in experimentally induced seizures in rats.

Anticonvulsant activity of four oxygenated cannabidiol derivatives.